Lipkin (Hebrew: ליפקין, Russian: Липкин) is a surname. Notable people with the surname include:

• Amnon Lipkin-Shahak (1944–2012), Israeli military officer
• Dmitry Lipkin, television writer and playwright
• Harry J. Lipkin (1921–2015), Israeli theoretical physicist
• Heather Slade-Lipkin, English pianist, harpsichordist and teacher
• Malcolm Lipkin (1932–2017), English composer
• Miles Jackson-Lipkin (1924–2012), jurist
• Nikolay Lipkin (born 1985), canoeist
• Pamela Lipkin (born 1952), plastic surgeon
• Semyon Lipkin (1911–2003), writer and poet
• Seymour Lipkin (1927–2015), pianist, conductor and teacher
• Simon Lipkin, British thespian
• Steven Barry Lipkin (born 1942), American songwriter and record producer
• W. Ian Lipkin (born 1952), the John Snow Professor of Epidemiology at the Mailman School of Public Health
• Yisrael Lipkin Salanter (1809–1883), Lithuanian Rabbi
• Yom Tov Lipman Lipkin (1846–1876), Lithuanian Jewish mathematician, inventor of Peaucellier–Lipkin linkage and son of Yisrael Lipkin Salanter
• Callie Lipkin (1976–), American commercial photographer